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Prescription weight-loss drugs

How well do weight-loss drugs work?

Prescription weight-loss drugs that you can use for more than 12 weeks lead to major weight loss compared with treatment that has no active medicine, called a placebo. Weight-loss medicine and lifestyle changes lead to greater weight loss than lifestyle changes alone.

Taking these medicines for a year can mean a loss of total body weight of 3% to 18% more than that lost with lifestyle changes alone. That may not seem like a lot. But losing 5% to 10% of your weight and keeping it off can help you. That amount of weight loss can lower blood pressure, blood sugar levels and levels of fats in the blood called triglycerides.