Interactions

Possible interactions include:

• Anticonvulsants. Taking folic acid with carbamazepine (Carbatrol, Tegretol, others), phenytoin (Dilantin, Phenytek) or valproate might lower the amount of the medicine in the blood.
• Barbiturates. A barbiturate is a medicine that acts as a central nervous system depressant. If you take folic acid with a barbiturate, the medicine might not work as well.
• Methotrexate (Trexall). Taking folic acid with this medicine when used to treat cancer could affect how well it works.
• Pyrimethamine (Daraprim). Taking folic acid with this medicine used to prevent malaria might affect how well it works.