Uncertain test results

Sometimes, testing finds gene changes that haven't been seen in other families with breast cancer, and there isn't enough information to know if these gene changes increase cancer risk. This type of result is known as a variant of uncertain significance.

Learning that you have a genetic variant of uncertain significance may lead to:

• Confusion and anxiety about your cancer risk.
• Frustration because there is not enough clear information about your risk of cancer.
• Challenges with making decisions about cancer screening, treatment and prevention.

A variant of uncertain significance may be reclassified over time as more information becomes available. Your genetic counselor may watch for these updates and let you know if the classification changes.