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Prednisone and other corticosteroids

Side effects of corticosteroids taken by mouth

Corticosteroids that you take by mouth affect your whole body. For this reason, they are the most likely type of corticosteroid to cause side effects. Side effects depend on the dose you take. They may include:

  • A buildup of fluid, causing swelling in the lower legs.
  • High blood pressure.
  • Mood swings, issues with memory and how you act, and other effects, such as not thinking clearly.
  • Trouble sleeping, called insomnia.
  • Upset stomach.
  • Weight gain in the belly, face and back of the neck.

When taking corticosteroids by mouth for a longer time, you may have:

  • Issues with the eyes, such as glaucoma or cataracts.
  • A round face, sometimes called moon face.
  • High blood sugar, which can start diabetes or make it worse.
  • Higher risk of infections.
  • Thinning of the bones, called osteoporosis.
  • Tiredness, not wanting to eat and muscle weakness.
  • Thin skin, bruising, acne and slower wound healing.