Safety and side effects

Side effects from SAMe are usually mild.

SAMe can cause:

• Digestive problems, such as nausea, diarrhea or constipation
• Mild insomnia
• Dizziness
• Irritability
• Anxiety
• Sweating

If you have bipolar disorder, don't take SAMe without talking to your doctor first. The supplement might increase anxiety and mania.

If you have a compromised immune system, talk to your doctor before taking SAMe. People who have a weakened immune system may be at increased risk of an infection caused by bacteria known as pneumocystis. SAMe may boost this microorganism's growth.