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Serotonin and norepinephrine reuptake inhibitors (SNRIs)

How SNRIs work

SNRIs ease depression by affecting chemical messengers called neurotransmitters that affect mood.

SNRIs block the reabsorption, also called reuptake, of the neurotransmitters serotonin (ser-o-TOE-nin) and norepinephrine (nor-ep-ih-NEF-rin) in the brain. Blocking reabsorption makes more of these chemicals available to help ease depression symptoms.