Evidence

Research on St. John's wort use for specific conditions shows:

• Depression. Several studies support the therapeutic benefit of St. John's wort in treating mild to moderate depression. In fact, some research has shown the supplement to be as effective as several prescription antidepressants. It's unclear whether it's beneficial in the treatment of severe depression. Because St. John's wort interacts with many medications, it might not be an appropriate choice, particularly if you take any prescription drugs.
• Menopausal symptoms. Some evidence suggests that taking St. John's wort alone or in combination with black cohosh or other herbs might reduce menopausal symptoms such as hot flashes.
• Somatic symptom disorder. Some studies indicate that St. John's wort might be beneficial for the treatment of this condition that causes severe anxiety about physical symptoms such as pain, weakness or shortness of breath.