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Ulcerative colitis vs. Crohn's disease

Transmural involvement

Ulcerative colitis. Inflammation that affects all layers of the bowel wall, known as transmural involvement, is not a hallmark of ulcerative colitis. In ulcerative colitis, the inflammation is limited to the mucosal layer. This is the innermost lining of the colon.

Crohn's disease. Transmural involvement is a feature of Crohn's disease. In Crohn's disease, inflammation can involve deeper layers of the intestinal wall. This can lead to narrowing of the intestine, tunnels in the tissue, known as fistulas, and pockets of infection, called abscesses.