Interactions

Check with your doctor before taking vitamin B-6 if you're using any medications. Possible drug interactions include:

• Altretamine. Taking vitamin B-6 with this chemotherapy drug might reduce its effectiveness, especially when also combined with the chemotherapy drug cisplatin.
• Barbiturates. Taking vitamin B-6 with a drug that acts as a central nervous system depressant (barbiturate) might decrease the drug's duration and intensity.
• Anticonvulsants. Taking vitamin B-6 with fosphenytoin (Cerebyx, Sesquient) or phenytoin (Dilantin, Phenytek) might decrease the drug's duration and intensity.
• Levodopa. Avoid taking vitamin B-6 with this drug used to treat Parkinson's disease. Vitamin B-6 might reduce the effectiveness of the drug.