Interactions

Vitamin E can affect the way that some medicines and supplements work, including:

• Alkylating agents and antitumor antibiotics. High doses of vitamin E may affect these chemotherapy medicines.
• Anticoagulant and antiplatelet medicines, herbs, and supplements. Use of vitamin E with these medicines, herbs, and supplements that lessen blood clotting may raise the risk of bleeding.
• Cytochrome P450 3A4 substrates, also called CYP3A4 substrates. Use caution when taking vitamin E and other medicines affected by these enzymes, such as omeprazole (Prilosec, Zegerid OTC).
• Statins and niacin. Taking vitamin E with cholesterol-lowering medicines called statins and niacin could keep niacin from working as it should. Niacin helps raise high-density lipoprotein, also called HDL, the "good cholesterol."
• Vitamin K. Taking vitamin E with vitamin K might keep vitamin K from working as it should.