How is Alli taken?

You take one 60-milligram Alli pill within an hour of a fat-containing meal up to three times a day. You should spread your daily fat intake over the three main meals. Fat intake should be no more than 30% of total calories. The manufacturer recommends a fat intake of about 15 grams a meal.

If you eat a meal that has no fat, then you don't need a dose of Alli. If you take Alli with a high-fat meal, you'll likely experience more-severe digestive side effects.

Alli can reduce the absorption of fat-soluble nutrients, including beta carotene and vitamins A, D, E and K. Take a multivitamin at least two hours after your last dose of Alli. For some people, this timing works out best to be at bedtime.