Genetic testing

Most experts don't routinely recommend genetic testing for late-onset Alzheimer's. In some instances of young-onset Alzheimer's, however, genetic testing may be helpful.

Usually, healthcare professionals don't test for APOE genes. The results can't fully predict who will get Alzheimer's disease. And healthcare professionals usually can diagnose Alzheimer's disease without the use of genetic testing.

But for treatment with certain medicines, called antiamyloid therapies, testing for APOE genes is important. If you're thinking about taking these medicines, testing can show how likely you are to have side effects. If you carry one or more APOE e4 variants, your risk of side effects is increased. Talk to your healthcare professional about whether APOE testing makes sense for you.

Testing for genetic variants that have been linked to young-onset Alzheimer's might be useful for someone showing symptoms or someone who has a family history of young-onset disease. Gene testing for young-onset Alzheimer's also may affect current and future participation in research trials and help with family planning.

Test results might have other effects, however. For instance, they might affect being able to get a job. And test results might keep you from getting certain types of insurance, such as disability, long-term care and life insurance.