Alpha-lipoic acid

Alpha-lipoic acid is an antioxidant found in many foods. The body can use antioxidants to prevent or manage a process that damages tissues called oxidative stress. Oxidative stress is part of the diabetic neuropathy disease process. Alpha-lipoic acid also may lower blood sugar levels, but more research is needed.

Small studies suggest that alpha-lipoic acid may improve diabetic neuropathy pain and other symptoms such as numbness and tingling. But results are mixed. Larger studies are needed.

In general, alpha-lipoic acid supplements are thought to be safe when taken as directed. But it's risky to take this supplement if your body is low on vitamin B-1, also called thiamin. When the body lacks thiamin, this is called a thiamin deficiency. Taking high doses of alpha-lipoic acid supplements might cause dangerous side effects such as seizures in people with a thiamin deficiency. Heavy alcohol use can be a risk factor for a thiamin deficiency. So don't use alpha-lipoic acid if you often drink large amounts of alcohol.

Foods that have alpha-lipoic acid include spinach, broccoli, potatoes, yams, carrots and red meat.