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Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a type of dementia that affects memory, thinking and social skills.

When people think about memory problems, Alzheimer's disease comes to mind. But LATE is a different disease and has its own characteristics. Sometimes, people may have signs and symptoms of both LATE and Alzheimer's disease.

People with LATE have problems with memory but often have a slower rate of clinical change than people with Alzheimer's disease. They may notice that over time it's more difficult to remember facts, conversations and events. People with LATE may repeat themselves often, be forgetful and have trouble finding the right words during conversations. They may also have difficulty understanding words.

Individuals with LATE may:

• Wander or get lost
• Make poor decisions
• Misplace things
• Have trouble driving
• Have difficulty keeping up with personal hygiene

Eventually, someone with LATE has trouble with daily living activities such as dressing, cooking or paying bills. The mental decline in LATE is slower than in other forms of dementia. This causes a slow, rather than a rapid, worsening of symptoms.