Selective serotonin reuptake inhibitors

Selective serotonin reuptake inhibitors (SSRIs) are medicines commonly used to treat depression and anxiety. They are considered the first line treatment for depression and anxiety during pregnancy and after birth.

SSRI use in the first trimester carries a low risk of birth defects and little to no risk for miscarriage. These medicines may be associated with a small risk of high blood pressure disorders in pregnancy such as preeclampsia, as well as preterm birth.

Untreated and undertreated mental health conditions are associated with poor outcomes for pregnant and postpartum people. In general, stopping effective medicines for mental health during pregnancy or the postpartum period increases the risk of relapse and is not recommended.

For people who have been treated with success with an antidepressant in the past, that antidepressant is often recommended as the first choice. For those starting a medicine for the first time during pregnancy or if previous medicines were unsuccessful, sertraline (Zoloft) is typically the preferred medicine due to reassuring safety data.

Discuss the benefits and risks of starting or continuing an SSRI during pregnancy with your healthcare professional.