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As you get older, your body goes through many changes. These changes can affect the way your body handles medicine. The changes often affect parts of the body that are used to break down medicines, such as the liver and kidneys. As you age, these organs don't work as well, which can cause medicines to build up to high levels or stay in the body for too long. This can cause side effects. So, you may become more sensitive to certain medicines or completely unable to take others.