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How gene mutations cause cancer

The genes affected in Lynch syndrome are responsible for correcting changes in the genetic code (mismatch repair genes).

Your genes contain DNA, which carries instructions for every chemical process in your body. As your cells grow and divide, they make copies of their DNA and it's not uncommon for some minor mistakes to occur.

Normal cells have mechanisms to recognize mistakes and repair them. But the cells of people who inherit one of the abnormal genes associated with Lynch syndrome lack the ability to repair these minor mistakes. An accumulation of these mistakes leads to increasing genetic damage within cells and eventually can cause the cells to become cancerous.