Diseases and Conditions

Multisystem inflammatory syndrome in children (MIS-C) and COVID-19

Symptoms

Signs and symptoms of multisystem inflammatory syndrome in children (MIS-C) include those below, though not all children have the same symptoms.

  • Fever that lasts 24 hours or longer
  • Vomiting
  • Diarrhea
  • Pain in the stomach
  • Skin rash
  • Feeling unusually tired
  • Fast heartbeat
  • Rapid breathing
  • Red eyes
  • Redness or swelling of the lips and tongue
  • Redness or swelling of the hands or feet
  • Headache, dizziness or lightheadedness
  • Enlarged lymph nodes

Emergency warning signs of MIS-C

  • Severe stomach pain
  • Difficulty breathing
  • Pale, gray or blue-colored skin, lips or nail beds — depending on skin tone
  • New confusion
  • Inability to wake up or stay awake

When to see a doctor

If your child has any of the emergency warning signs listed above — or is severely sick with other signs and symptoms — get care immediately. Take your child to the nearest emergency department or call 911 or your local emergency number.

If your child isn't severely ill but shows other signs or symptoms of MIS-C, contact your child's doctor right away for advice. Doctors may want to do tests — such as blood tests, or imaging tests of the chest, heart or abdomen — to check for areas of inflammation and other signs of MIS-C.