Complications

Average progression of primary lateral sclerosis can take as long as 20 years and has highly variable effects from person to person. Some people continue to walk, but others eventually need to use wheelchairs or other assistive devices.

In most cases, adult-onset PLS isn't thought to shorten life expectancy, but it can gradually affect the quality of your life as more muscles become disabled. Weaker muscles can cause you to fall, which can result in injuries. Problems with chewing and swallowing may result in poor nutrition. Performing activities of daily living, such as bathing and dressing, may become difficult.