Symptoms

Usually within the first year of life, growth of a child with progeria slows markedly, but motor development and intelligence remain normal.

Signs and symptoms of this progressive disorder include a distinctive appearance:

• Slowed growth, with below-average height and weight
• Narrowed face, small lower jaw, thin lips and beaked nose
• Head disproportionately large for the face
• Prominent eyes and incomplete closure of the eyelids
• Hair loss, including eyelashes and eyebrows
• Thinning, spotty, wrinkled skin
• Visible veins
• High-pitched voice

Signs and symptoms also include health issues:

• Severe progressive heart and blood vessel (cardiovascular) disease
• Hardening and tightening of skin on the trunk and extremities (similar to scleroderma)
• Delayed and abnormal tooth formation
• Some hearing loss
• Loss of fat under the skin and loss of muscle mass
• Skeletal abnormalities and fragile bones
• Stiff joints
• Hip dislocation
• Insulin resistance

When to see a doctor

Progeria is usually detected in infancy or early childhood, often at regular checkups, when a baby first shows the characteristic signs of premature aging.

If you notice changes in your child that could be signs and symptoms of progeria, or you have any concerns about your child's growth or development, make an appointment with your child's doctor.