Acetaminophen

Acetaminophen is usually recommended first for mild to moderate pain. It might be taken for pain due to a skin injury, headache, or conditions that affect the muscles and bones. Acetaminophen is often prescribed to help manage osteoarthritis and back pain. It also may be combined with opioids to reduce the amount of opioid needed.

• Generic (brand) names. Acetaminophen (Tylenol, others).
• How it works. Acetaminophen is thought to block the production of prostaglandins in the central nervous system. Prostaglandins are hormonelike substances that are involved in pain and inflammation. Unlike NSAIDs, acetaminophen doesn't target inflammation at the site of injury — only pain.
• Benefits and risks. Acetaminophen is generally considered safer than other pain relievers. It doesn't cause side effects such as stomach pain and bleeding. However, taking more than the recommended dose or taking acetaminophen with alcohol increases the risk of kidney damage and liver failure over time.
• Bottom line. Acetaminophen is generally a safe option to try first for many types of pain, including chronic pain. Ask your healthcare professional for guidance about safely taking acetaminophen if you take other medications. Acetaminophen is not as effective as NSAIDs for the treatment of knee and hip pain related to osteoarthritis.