Evidence

Research on DHEA for specific conditions includes:

• Aging. In theory, taking DHEA supplements to maintain DHEA levels could slow the aging process, possibly improving well-being, thinking skills and body composition. But so far research hasn't proved this to be true. More studies are needed to better understand whether DHEA supplementation can counteract some of the effects of aging. A small study suggested that taking DHEA supplements might improve skin hydration and firmness and reduce aging spots in older adults.
• Depression. Some research finds that DHEA might be helpful in treating depression.
• Osteoporosis. Study findings on the effects of DHEA supplementation in the treatment of osteoporosis are mixed. More research is needed to find out whether taking DHEA supplements improves bone density in older adults with low DHEA.
• Vaginal atrophy. Research suggests that DHEA can help improve vaginal dryness in postmenopausal women when treatment is given through the vagina.

Research on the effects of DHEA on muscle strength and physical performance had mixed results, but most studies indicate DHEA supplementation has no effect on muscle strength in younger or older adults. The National Collegiate Athletic Association has banned DHEA use among athletes.

DHEA might eventually prove to have benefits in treating people diagnosed with certain conditions, such as adrenal insufficiency and lupus. However, further studies are needed.

Studies have shown quality control of this supplement to often be low.