Mayo Clinic Care Network Content
Articles

Folate (folic acid)

Safety and side effects

When taken by mouth at suggested doses, folic acid is likely safe.

Taking high doses of folic acid by mouth can cause:

  • A bitter taste in the mouth.
  • Nausea.
  • Loose stools.
  • Confusion.
  • Irritability.
  • Trouble sleeping.
  • Stomach cramps.

People with allergies might have a reaction to folic acid supplements. Warning signs of an allergic reaction include:

  • Skin rash.
  • Itching.
  • Skin color changes, such as purple or brown depending on your skin color.
  • Difficulty breathing.

If you take too much folic acid, it comes out of the body in urine.

When a person takes a high amount of a folic acid supplement, it can be hard to know if the person has enough vitamin B-12. Taking folic acid supplements can help correct low blood counts, but it won't repair nerve damage from not having enough vitamin B-12. Taking a supplement that has 100% of the Daily Value of both folic acid and vitamin B-12 can help prevent this issue.