If you have a minor sprain, you can probably treat it at home with R.I.C.E., which stands for rest, ice, compress and elevate. Rest the injured area, but don't avoid all activity. Ice the area as soon as possible after the injury. Compress the area with an elastic wrap or bandage. Elevate the injured limb above your heart whenever possible to limit swelling. As the pain and swelling improve, gently begin using the injured area. Over-the-counter pain relievers, such as ibuprofen and acetaminophen, may be helpful to manage pain during the healing process.